Russ Altman interviews distinquished innovators in the science and art of Biomedical Informatics. Altman interviewed Robert Langridge on August 20th, 2002 at Stanford University's School of Medicine.  

Molecular Graphics Video  
Robert Langridge Photo
Robert Langridge
Professor Emeritus of Pharmaceutical Chemistry and of Biochemistry and Biophysics at the University of California, San Francisco. From 1992 to 1994 he was chairman of the Joint UC Berkeley/UC San Francisco Graduate Program in Bioengineering and founder and director of the UCSF Computer Graphics Laboratory from 1976 to 1994.

Born in England in 1933, Robert Langridge received his B.Sc. in Physics with First Class Honours in 1954 and his Ph.D in Crystallography in 1957 from the University of London. His dissertation was on X-Ray crystallographic, model building and computational studies of the structure of DNA, including the first application of a stored program digital computer (the IBM 650) to the analysis of DNA structure. His research was supervised by Maurice Wilkins (who shared the Nobel Prize with Watson and Crick in 1962).

For more information about Robert Langridge please visit his website:

Russ Altman Photo

Russ Altman
My primary interests are in the application of computing technologies to basic molecular biological problems, now referred to as bioinformatics. I am particularly interested in the analysis of protein and RNA structure and function, both in a problem-centered manner and on a functional genomic scale. My core work has been the development of probabilistic algorithms for the determination of protein structure from sparse and uncertain experimental data. These algorithms have been shown to have some advantages over other methods of structure determination including the ability to calculate not only a protein conformation, but also an explicit estimate of the uncertainty in the position of each atom.

For more information about Russ Altman, please visit his website: